As a main regulator of melanocyte development and an key melanoma oncogene, microphthalmia-associated transcription factor (MITF) is one of the proteins in the basic helix-loop-helix zipper (bHLHZip) transcription factor family.The study on the detailed binding specificity of the MITF/DNA complex has been a challenge.MITF-DNA interaction details an
Adaptation opportunities and maladaptive outcomes in climate vulnerability hotspots of northern Ghana
How climate change adaptation practices can constrain development and deliver maladaptive outcomes in vulnerability hotspots is yet to be explored in-depth using case study analyses.This paper explores the effects of climate change coping and adaptation responses in three case study villages across the Central Gonja district of northern Ghana.The s
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: Implications for PET imaging of neuroinflammation in lentiviral encephalitis
HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hair mask hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated brain macrophages in HIVE.Using cel